Publications

⭐ Note: Selected publications are highlighted first, followed by the complete list of other publications.

Selected Publications

  1. Developmental reprogramming in melanocortin neurons modulates diet-induced obesity
    Li Li, Baijie Xu, Xiameng Chen, Rong Wan, Amanda G. Almeida, Steven C Wyler, Swati, and Chen Liu
    under review, 2025
  2. bioRxiv_logo.jpg
    Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia
    Li Li, Ciria C Hernandez, Luis E Gimenez, Baijie Xu, Naima S Dahir, Swati, Shari G Birnbaum, Roger D Cone, and Chen Liu
    bioRxiv, 2024
  3. 20_li2023sample.jpg
    Sample enrichment for single-nucleus sequencing using concanavalin A-conjugated magnetic beads
    Li Li, Baijie Xu, and Chen Liu
    STAR protocols, 2023
    DOI PDF
  4. JEM.png
    Delineating a serotonin 1B receptor circuit for appetite suppression in mice
    Li Li, Steven C. Wyler, Luis A. León-Mercado, Baijie Xu, Youjin Oh, Swati, Xiameng Chen, Rong Wan, Amanda G. Arnold, Lin Jia, Guanlin Wang, Katherine Nautiyal, René Hen, Jong-Woo Sohn, and Chen Liu
    Journal of Experimental Medicine, 2022
    DOI PDF
  5. NC.png
    Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice
    Min Li, Li Li, Baoguo Li, Catherine Hambly, Guanlin Wang, Yingga Wu, Zengguang Jin, Anyongqi Wang, Chaoqun Niu, Christian Wolfrum, and John R. Speakman
    Nature communications, 2021
    DOI PDF
  6. JEM.png
    The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain
    Li Li, Eun-Seon Yoo, Xiujuan Li, Steven C. Wyler, Xiameng Chen, Rong Wan, Amanda G. Arnold, Shari G. Birnbaum, Lin Jia, Jong-Woo Sohn, and Chen Liu
    Journal of Experimental Medicine, 2021
    DOI PDF
  7. MAM_logo.jpg
    Switching on the furnace: regulation of heat production in brown adipose tissue
    Li Li, Baoguo Li, Min Li, and John R Speakman
    Molecular aspects of medicine, 2019
    DOI PDF
  8. 6_li2019microbiota.jpg
    Microbiota depletion impairs thermogenesis of brown adipose tissue and browning of white adipose tissue
    Baoguo Li, Li Li, Min Li, Sin Man Lam, Guanlin Wang, Yingga Wu, Hanlin Zhang, Chaoqun Niu, Xueying Zhang, Xue Liu, Catherine Hambly, Wanzhu Jin, Guanghou Shui, and John R. Speakman
    Cell Reports, 2019
    DOI PDF
  9. 5_hu2018dietary.jpg
    Dietary fat, but not protein or carbohydrate, regulates energy intake and causes adiposity in mice
    Sumei Hu, Lu Wang, Dengbao Yang, Li Li, Jacques Togo, Yingga Wu, Quansheng Liu, Baoguo Li, Min Li, Guanlin Wang, Xueying Zhang, Chaoqun Niu, Jianbo Li, Yanchao Xu, Elspeth Couper, Andrew Whittington-Davies, Mohsen Mazidi, Lijuan Luo, Shengnan Wang, Alex Douglas, and John R. Speakman
    Cell metabolism, 2018
    DOI PDF
  10. molecular_metabolism_logo.jpeg
    Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo
    Li Li, Baoguo Li, Min Li, Chaoqun Niu, Guanlin Wang, Ting Li, Elżbieta Król, Wanzhu Jin, and John R Speakman
    Molecular metabolism, 2017
    DOI PDF

Other Publications

  1. Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis
    Baijie Xu, Katherine Lawler, Steven C. Wyler, Li Li, Swati, Julia M. Keogh, Xiameng Chen, Rong Wan, Amanda G. Almeida, Susan Kirsch, Kathleen G. Mountjoy, Joel K. Elmquist, I. Sadaf Farooqi, and Chen Liu
    Science translational medicine, 2025
    DOI PDF
  2. The hedonic overdrive model best explains high-fat diet-induced obesity in C57BL/6 mice
    Lin Gao, Sumei Hu, Dengbao Yang, Lu Wang, Jacques Togo, Yingga Wu, Baoguo Li, Min Li, Guanlin Wang, Xueying Zhang, Li Li, Yanchao Xu, Moshen Mazidi, Elspeth Couper, Andrew Whittington Davies, Chaoqun Niu, and John R. Speakman
    Obesity, 2024
    DOI PDF
  3. Maternal high fat diet in lactation impacts hypothalamic neurogenesis and neurotrophic development, leading to later life susceptibility to obesity in male but not female mice
    Yanchao Xu, Dengbao Yang, Lu Wang, Elżbieta Król, Mohsen Mazidi, Li Li, Yi Huang, Chaoqun Niu, Xue Liu, Sin Man Lam, Guanghou Shui, Alex Douglas, and John R. Speakman
    Advanced Science, 2023
    DOI PDF
  4. Hyperleptinemia contributes to antipsychotic drug–associated obesity and metabolic disorders
    Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C. Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M. Kusminski, Ningyan Zhang, Zhiqiang An, Joel K. Elmquist, Olivia Osborn, Chen Liu, and Philipp E. Scherer
    Science translational medicine, 2023
    DOI PDF
  5. Calorie restriction and calorie dilution have different impacts on body fat, metabolism, behavior, and hypothalamic gene expression
    Xue Liu, Zengguang Jin, Stephanie Summers, Davina Derous, Min Li, Baoguo Li, Li Li, and John R Speakman
    Cell Reports, 2022
    DOI PDF
  6. Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice
    Yingga Wu, Cara L. Green, Guanlin Wang, Dengbao Yang, Li Li, Baoguo Li, Lu Wang, Min Li, Jianbo Li, Yanchao Xu, Xueying Zhang, Chaoqun Niu, Sumei Hu, Jacques Togo, Mohsen Mazidi, Davina Derous, Alex Douglas, and John R. Speakman
    Aging Cell, 2022
    DOI PDF
  7. Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in mice
    Yingga Wu, Sumei Hu, Dengbao Yang, Li Li, Baoguo Li, Lu Wang, Min Li, Guanlin Wang, Jianbo Li, Yanchao Xu, Xueying Zhang, Chaoqun Niu, and John R. Speakman
    Frontiers in Nutrition, 2022
    DOI PDF
  8. A single nucleotide mutation in the dual-oxidase 2 (DUOX2) gene causes some of the panda’s unique metabolic phenotypes
    Agata M Rudolf, Qi Wu, Li Li, Jun Wang, Yi Huang, Jacques Togo, Christopher Liechti, Min Li, Chaoqun Niu, Yonggang Nie, Fuwen Wei, and John R Speakman
    National Science Review, 2022
    DOI PDF
  9. G\alphai/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents
    Eun-Seon Yoo, Li Li, Lin Jia, Caleb C. Lord, Charlotte E. Lee, Shari G. Birnbaum, Claudia R. Vianna, Eric D. Berglund, Kathryn A. Cunningham, Yong Xu, Jong-Woo Sohn, and Chen Liu
    Cell reports, 2021
    DOI PDF
  10. Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
    Yingga Wu, Baoguo Li, Li Li, Sharon E. Mitchell, Cara L. Green, Giuseppe D’Agostino, Guanlin Wang, Lu Wang, Min Li, Jianbo Li, Chaoqun Niu, Zengguang Jin, Anyongqi Wang, Yu Zheng, Alex Douglas, and John R. Speakman
    Cell Metabolism, 2021
    DOI PDF
  11. Effects of dietary macronutrients and body composition on glucose homeostasis in mice
    Sumei Hu, Jacques Togo, Lu Wang, Yingga Wu, Dengbao Yang, Yanchao Xu, Li Li, Baoguo Li, Min Li, Jianbo Li, Guanlin Wang, Xueying Zhang, Chaoqun Niu, Mohsen Mazidi, Alex Douglas, and John R Speakman
    National Science Review, 2021
    DOI PDF
  12. Limits to sustained energy intake. XXXI. Effect of graded levels of dietary fat on lactation performance in Swiss mice
    Yi Huang, Jazmin Osorio Mendoza, Catherine Hambly, Baoguo Li, Zengguang Jin, Li Li, Moshen Madizi, Sumei Hu, and John R Speakman
    Journal of Experimental Biology, 2020
    DOI PDF
  13. Comparative transcriptomic analyses of developing melanocortin neurons reveal new regulators for the anorexigenic neuron identity
    Xiameng Chen, Steven C Wyler, Li Li, Amanda G Arnold, Rong Wan, Lin Jia, Mark A Landy, Helen C Lai, Pin Xu, and Chen Liu
    Journal of Neuroscience, 2020
    DOI PDF
  14. No seasonal variation in physical activity of Han Chinese living in Beijing
    Guanlin Wang, Baoguo Li, Xueying Zhang, Chaoqun Niu, Jianbo Li, Li Li, and John R Speakman
    International Journal of Behavioral Nutrition and Physical Activity, 2017
    DOI PDF
  15. Limits to sustained energy intake XXV: milk energy output and thermogenesis in Swiss mice lactating at thermoneutrality
    Zhi-Jun Zhao, Li Li, Deng-Bao Yang, Qing-Sheng Chi, Catherine Hambly, and John R Speakman
    Scientific Reports, 2016
    DOI PDF
  16. Limits to sustained energy intake. XIX. A test of the heat dissipation limitation hypothesis in Mongolian gerbils (Meriones unguiculatus)
    Deng-Bao Yang, Li Li, Lu-Ping Wang, Qing-Sheng Chi, Catherine Hambly, De-Hua Wang, and John R Speakman
    Journal of Experimental Biology, 2013
    DOI PDF

↑ Back to top