Publications

⭐ Note: Selected publications are highlighted first, followed by the complete list of other publications.

Selected Publications

1. 

   Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced weight gain in female mice

   Li Li, Hernandez Ciria C., Gimenez Luis E., Xu Baijie, Dahir Naima S., Peisley Alys, Wu Zan, Chen Meilin, Serrato Alexandra, Wan Rong, Swati, Birnbaum Shari G., Cone Roger D., and Liu Chen

   Nature communications, 2026

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2. 

   Developmental reprogramming in melanocortin neurons modulates diet-induced obesity in mice

   Baijie Xu, Li Li, Meilin Chen, Zan Wu, Xiameng Chen, Swati, Rong Wan, Amanda G. Almeida, Steven C Wyler, and Chen Liu

   Neuron, 2026

   DOI PDF

3. 

   Sample enrichment for single-nucleus sequencing using concanavalin A-conjugated magnetic beads

   Li Li, Baijie Xu, and Chen Liu

   STAR protocols, 2023

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4. 

   Delineating a serotonin 1B receptor circuit for appetite suppression in mice

   Li Li, Steven C. Wyler, Luis A. León-Mercado, Baijie Xu, Youjin Oh, Swati, Xiameng Chen, Rong Wan, Amanda G. Arnold, Lin Jia, Guanlin Wang, Katherine Nautiyal, René Hen, Jong-Woo Sohn, and Chen Liu

   Journal of Experimental Medicine, 2022

   DOI PDF

5. 

   Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice

   Min Li, Li Li, Baoguo Li, Catherine Hambly, Guanlin Wang, Yingga Wu, Zengguang Jin, Anyongqi Wang, Chaoqun Niu, Christian Wolfrum, and John R. Speakman

   Nature communications, 2021

   DOI PDF

6. 

   The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain

   Li Li, Eun-Seon Yoo, Xiujuan Li, Steven C. Wyler, Xiameng Chen, Rong Wan, Amanda G. Arnold, Shari G. Birnbaum, Lin Jia, Jong-Woo Sohn, and Chen Liu

   Journal of Experimental Medicine, 2021

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7. 

   Switching on the furnace: regulation of heat production in brown adipose tissue

   Li Li, Baoguo Li, Min Li, and John R Speakman

   Molecular aspects of medicine, 2019

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8. 

   Microbiota depletion impairs thermogenesis of brown adipose tissue and browning of white adipose tissue

   Baoguo Li, Li Li, Min Li, Sin Man Lam, Guanlin Wang, Yingga Wu, Hanlin Zhang, Chaoqun Niu, Xueying Zhang, Xue Liu, Catherine Hambly, Wanzhu Jin, Guanghou Shui, and John R. Speakman

   Cell Reports, 2019

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9. 

   Dietary fat, but not protein or carbohydrate, regulates energy intake and causes adiposity in mice

   Sumei Hu, Lu Wang, Dengbao Yang, Li Li, Jacques Togo, Yingga Wu, Quansheng Liu, Baoguo Li, Min Li, Guanlin Wang, Xueying Zhang, Chaoqun Niu, Jianbo Li, Yanchao Xu, Elspeth Couper, Andrew Whittington-Davies, Mohsen Mazidi, Lijuan Luo, Shengnan Wang, Alex Douglas, and John R. Speakman

   Cell metabolism, 2018

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10. 

    Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo

    Li Li, Baoguo Li, Min Li, Chaoqun Niu, Guanlin Wang, Ting Li, Elżbieta Król, Wanzhu Jin, and John R Speakman

    Molecular metabolism, 2017

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Other Publications

1. Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis

   Baijie Xu, Katherine Lawler, Steven C. Wyler, Li Li, Swati, Julia M. Keogh, Xiameng Chen, Rong Wan, Amanda G. Almeida, Susan Kirsch, Kathleen G. Mountjoy, Joel K. Elmquist, I. Sadaf Farooqi, and Chen Liu

   Science translational medicine, 2025

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2. The hedonic overdrive model best explains high-fat diet-induced obesity in C57BL/6 mice

   Lin Gao, Sumei Hu, Dengbao Yang, Lu Wang, Jacques Togo, Yingga Wu, Baoguo Li, Min Li, Guanlin Wang, Xueying Zhang, Li Li, Yanchao Xu, Moshen Mazidi, Elspeth Couper, Andrew Whittington Davies, Chaoqun Niu, and John R. Speakman

   Obesity, 2024

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3. Maternal high fat diet in lactation impacts hypothalamic neurogenesis and neurotrophic development, leading to later life susceptibility to obesity in male but not female mice

   Yanchao Xu, Dengbao Yang, Lu Wang, Elżbieta Król, Mohsen Mazidi, Li Li, Yi Huang, Chaoqun Niu, Xue Liu, Sin Man Lam, Guanghou Shui, Alex Douglas, and John R. Speakman

   Advanced Science, 2023

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4. Hyperleptinemia contributes to antipsychotic drug–associated obesity and metabolic disorders

   Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C. Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M. Kusminski, Ningyan Zhang, Zhiqiang An, Joel K. Elmquist, Olivia Osborn, Chen Liu, and Philipp E. Scherer

   Science translational medicine, 2023

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5. Calorie restriction and calorie dilution have different impacts on body fat, metabolism, behavior, and hypothalamic gene expression

   Xue Liu, Zengguang Jin, Stephanie Summers, Davina Derous, Min Li, Baoguo Li, Li Li, and John R Speakman

   Cell Reports, 2022

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6. Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice

   Yingga Wu, Cara L. Green, Guanlin Wang, Dengbao Yang, Li Li, Baoguo Li, Lu Wang, Min Li, Jianbo Li, Yanchao Xu, Xueying Zhang, Chaoqun Niu, Sumei Hu, Jacques Togo, Mohsen Mazidi, Davina Derous, Alex Douglas, and John R. Speakman

   Aging Cell, 2022

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7. Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in mice

   Yingga Wu, Sumei Hu, Dengbao Yang, Li Li, Baoguo Li, Lu Wang, Min Li, Guanlin Wang, Jianbo Li, Yanchao Xu, Xueying Zhang, Chaoqun Niu, and John R. Speakman

   Frontiers in Nutrition, 2022

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8. A single nucleotide mutation in the dual-oxidase 2 (DUOX2) gene causes some of the panda’s unique metabolic phenotypes

   Agata M Rudolf, Qi Wu, Li Li, Jun Wang, Yi Huang, Jacques Togo, Christopher Liechti, Min Li, Chaoqun Niu, Yonggang Nie, Fuwen Wei, and John R Speakman

   National Science Review, 2022

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9. G\alphai/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents

   Eun-Seon Yoo, Li Li, Lin Jia, Caleb C. Lord, Charlotte E. Lee, Shari G. Birnbaum, Claudia R. Vianna, Eric D. Berglund, Kathryn A. Cunningham, Yong Xu, Jong-Woo Sohn, and Chen Liu

   Cell reports, 2021

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10. Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

    Yingga Wu, Baoguo Li, Li Li, Sharon E. Mitchell, Cara L. Green, Giuseppe D’Agostino, Guanlin Wang, Lu Wang, Min Li, Jianbo Li, Chaoqun Niu, Zengguang Jin, Anyongqi Wang, Yu Zheng, Alex Douglas, and John R. Speakman

    Cell Metabolism, 2021

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11. Effects of dietary macronutrients and body composition on glucose homeostasis in mice

    Sumei Hu, Jacques Togo, Lu Wang, Yingga Wu, Dengbao Yang, Yanchao Xu, Li Li, Baoguo Li, Min Li, Jianbo Li, Guanlin Wang, Xueying Zhang, Chaoqun Niu, Mohsen Mazidi, Alex Douglas, and John R Speakman

    National Science Review, 2021

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12. Limits to sustained energy intake. XXXI. Effect of graded levels of dietary fat on lactation performance in Swiss mice

    Yi Huang, Jazmin Osorio Mendoza, Catherine Hambly, Baoguo Li, Zengguang Jin, Li Li, Moshen Madizi, Sumei Hu, and John R Speakman

    Journal of Experimental Biology, 2020

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13. Comparative transcriptomic analyses of developing melanocortin neurons reveal new regulators for the anorexigenic neuron identity

    Xiameng Chen, Steven C Wyler, Li Li, Amanda G Arnold, Rong Wan, Lin Jia, Mark A Landy, Helen C Lai, Pin Xu, and Chen Liu

    Journal of Neuroscience, 2020

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14. No seasonal variation in physical activity of Han Chinese living in Beijing

    Guanlin Wang, Baoguo Li, Xueying Zhang, Chaoqun Niu, Jianbo Li, Li Li, and John R Speakman

    International Journal of Behavioral Nutrition and Physical Activity, 2017

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15. Limits to sustained energy intake XXV: milk energy output and thermogenesis in Swiss mice lactating at thermoneutrality

    Zhi-Jun Zhao, Li Li, Deng-Bao Yang, Qing-Sheng Chi, Catherine Hambly, and John R Speakman

    Scientific Reports, 2016

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16. Limits to sustained energy intake. XIX. A test of the heat dissipation limitation hypothesis in Mongolian gerbils (Meriones unguiculatus)

    Deng-Bao Yang, Li Li, Lu-Ping Wang, Qing-Sheng Chi, Catherine Hambly, De-Hua Wang, and John R Speakman

    Journal of Experimental Biology, 2013

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